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The dissolution of the League of Nations can be attributed significantly to the fact that it was largely ignored by major world powers, including the United States. The League was established after World War I with the aim of maintaining peace and preventing future conflicts through collective security and diplomacy. However, its effectiveness was severely undermined by the absence of key nations. The United States, despite being a principal architect of the League, never joined it due to congressional opposition, which greatly weakened its authority and ability to act decisively.

Additionally, many other major powers did not fully commit to the League's mandates, leading to a lack of enforcement capabilities. For instance, the League's inability to prevent aggression from countries like Japan in Manchuria and Italy in Ethiopia highlighted its weaknesses. Without the backing of significant nations, the League struggled to achieve its goals, ultimately contributing to its failure and eventual dissolution, paving the way for the formation of the United Nations after World War II to address similar issues more effectively.